Developmentally-induced Mll1 loss reveals defects in postnatal haematopoiesis

The Mixed Lineage Leukemia (MLL) gene is disrupted by chromosomal translocations in acute leukemia, producing a fusion oncogene with altered properties relative to the wild-type gene. Murine loss-of-function studies have demonstrated an essential role for Mll in developing the haematopoietic system,...

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Detalles Bibliográficos
Autores principales: Gan, Tao, Jude, Craig D., Zaffuto, Kristin, Ernst, Patricia
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954260/
https://www.ncbi.nlm.nih.gov/pubmed/20724987
http://dx.doi.org/10.1038/leu.2010.171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954260/
https://www.ncbi.nlm.nih.gov/pubmed/20724987
http://dx.doi.org/10.1038/leu.2010.171

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