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Developmentally-induced Mll1 loss reveals defects in postnatal haematopoiesis
The Mixed Lineage Leukemia (MLL) gene is disrupted by chromosomal translocations in acute leukemia, producing a fusion oncogene with altered properties relative to the wild-type gene. Murine loss-of-function studies have demonstrated an essential role for Mll in developing the haematopoietic system,...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954260/ https://www.ncbi.nlm.nih.gov/pubmed/20724987 http://dx.doi.org/10.1038/leu.2010.171 |