Elevation of Global O-GlcNAc in Rodents Using a Selective O-GlcNAcase Inhibitor Does Not Cause Insulin Resistance or Perturb Glucohomeostasis

The O-GlcNAc modification is proposed to be a nutrient sensor with studies suggesting that global increases in O-GlcNAc levels cause insulin resistance and impaired glucohomeostasis. We address this hypothesis by using a potent and selective inhibitor of O-GlcNAcase, known as NButGT, in a series of...

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Detalles Bibliográficos
Autores principales: Macauley, Matthew S., Shan, Xiaoyang, Yuzwa, Scott A., Gloster, Tracey M., Vocadlo, David J.
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954292/
https://www.ncbi.nlm.nih.gov/pubmed/20851344
http://dx.doi.org/10.1016/j.chembiol.2010.07.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954292/
https://www.ncbi.nlm.nih.gov/pubmed/20851344
http://dx.doi.org/10.1016/j.chembiol.2010.07.005

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