Domain Metastability: A Molecular Basis for Immunoglobulin Deposition?

We present the crystal structure of an immunoglobulin light-chain-like domain, CTLA-4, as a strand-swapped dimer displaying cis–trans proline isomerisation and native-like hydrogen bonding. We also show that CTLA-4 can form amyloid-like fibres and amorphous deposits explainable by the same strand sw...

Descripción completa

Detalles Bibliográficos
Autores principales: Sonnen, Andreas F.-P., Yu, Chao, Evans, Edward J., Stuart, David I., Davis, Simon J., Gilbert, Robert J.C.
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2010
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954335/
https://www.ncbi.nlm.nih.gov/pubmed/20394753
http://dx.doi.org/10.1016/j.jmb.2010.04.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954335/
https://www.ncbi.nlm.nih.gov/pubmed/20394753
http://dx.doi.org/10.1016/j.jmb.2010.04.011

Ejemplares similares