A Novel Adaptive Method for the Analysis of Next-Generation Sequencing Data to Detect Complex Trait Associations with Rare Variants Due to Gene Main Effects and Interactions

There is solid evidence that rare variants contribute to complex disease etiology. Next-generation sequencing technologies make it possible to uncover rare variants within candidate genes, exomes, and genomes. Working in a novel framework, the kernel-based adaptive cluster (KBAC) was developed to pe...

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Detalles Bibliográficos
Autores principales: Liu, Dajiang J., Leal, Suzanne M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954824/
https://www.ncbi.nlm.nih.gov/pubmed/20976247
http://dx.doi.org/10.1371/journal.pgen.1001156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954824/
https://www.ncbi.nlm.nih.gov/pubmed/20976247
http://dx.doi.org/10.1371/journal.pgen.1001156

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