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Controlling Cellular P-TEFb Activity by the HIV-1 Transcriptional Transactivator Tat

The human immunodeficiency virus 1 (HIV-1) transcriptional transactivator (Tat) is essential for synthesis of full-length transcripts from the integrated viral genome by RNA polymerase II (Pol II). Tat recruits the host positive transcription elongation factor b (P-TEFb) to the HIV-1 promoter throug...

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Detalles Bibliográficos
Autores principales: Muniz, Lisa, Egloff, Sylvain, Ughy, Bettina, Jády, Beáta E., Kiss, Tamás
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954905/
https://www.ncbi.nlm.nih.gov/pubmed/20976203
http://dx.doi.org/10.1371/journal.ppat.1001152