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Molecular evolution and the role of oxidative stress in the expansion and functional diversification of cytosolic glutathione transferases

BACKGROUND: Cytosolic glutathione transferases (cGST) are a large group of ubiquitous enzymes involved in detoxification and are well known for their undesired side effects during chemotherapy. In this work we have performed thorough phylogenetic analyses to understand the various aspects of the evo...

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Detalles Bibliográficos
Autores principales: da Fonseca, Rute R, Johnson, Warren E, O'Brien, Stephen J, Vasconcelos, Vítor, Antunes, Agostinho
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955027/
https://www.ncbi.nlm.nih.gov/pubmed/20843339
http://dx.doi.org/10.1186/1471-2148-10-281