ETV1 is a lineage-specific survival factor in GIST and cooperates with KIT in oncogenesis

Gastrointestinal stromal tumour (GIST) is the most common human sarcoma and is primarily defined by activating mutations in the KIT or PDGFRA receptor tyrosine kinases1,2. KIT is highly expressed in interstitial cells of Cajal (ICCs)—the presumed cell of origin for GIST—as well as in hematopoietic s...

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Detalles Bibliográficos
Autores principales: Chi, Ping, Chen, Yu, Zhang, Lei, Guo, Xingyi, Wongvipat, John, Shamu, Tambudzai, Fletcher, Jonathan A., Dewell, Scott, Maki, Robert G., Zheng, Deyou, Antonescu, Cristina R., Allis, C. David, Sawyers, Charles L.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955195/
https://www.ncbi.nlm.nih.gov/pubmed/20927104
http://dx.doi.org/10.1038/nature09409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955195/
https://www.ncbi.nlm.nih.gov/pubmed/20927104
http://dx.doi.org/10.1038/nature09409

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