The Lack of ADAM17 Activity during Embryonic Development Causes Hemorrhage and Impairs Vessel Formation

BACKGROUND: ADAM17/TACE activity is important during embryonic development. We wished to investigate possible roles of this metalloprotease, focusing on vascular development. METHODOLOGY/PRINCIPAL FINDINGS: Mice mutant in the enzymatic activity of ADAM17 were examined at various stages of embryonic...

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Detalles Bibliográficos
Autores principales: Canault, Matthias, Certel, Kaan, Schatzberg, Daphne, Wagner, Denisa D., Hynes, Richard O.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955552/
https://www.ncbi.nlm.nih.gov/pubmed/20976179
http://dx.doi.org/10.1371/journal.pone.0013433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955552/
https://www.ncbi.nlm.nih.gov/pubmed/20976179
http://dx.doi.org/10.1371/journal.pone.0013433

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