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Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2
BACKGROUND: Proteinase-activated-receptor-2 (PAR(2)) is a seven transmembrane receptor that can activate two separate signaling arms: one through Gαq and Ca(2+ )mobilization, and a second through recruitment of β-arrestin scaffolds. In some cases downstream targets of the Gαq/Ca(2+ )signaling arm ar...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955585/ https://www.ncbi.nlm.nih.gov/pubmed/20858278 http://dx.doi.org/10.1186/1471-2091-11-36 |