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Down-regulation of the Nucleotide Excision Repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells

BACKGROUND: Drug resistance is one of the major obstacles limiting the activity of anticancer agents. Activation of DNA repair mechanism often accounts for increase resistance to cancer chemotherapy. RESULTS: We present evidence that nemorubicin, a doxorubicin derivative currently in clinical evalua...

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Detalles Bibliográficos
Autores principales:	Sabatino, Maria Antonietta, Marabese, Mirko, Ganzinelli, Monica, Caiola, Elisa, Geroni, Cristina, Broggini, Massimo
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955619/ https://www.ncbi.nlm.nih.gov/pubmed/20868484 http://dx.doi.org/10.1186/1476-4598-9-259

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