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Targeting poly(ADP-ribose) polymerase activity for cancer therapy
Poly(ADP-ribosyl)ation is a ubiquitous protein modification found in mammalian cells that modulates many cellular responses, including DNA repair. The poly(ADP-ribose) polymerase (PARP) family catalyze the formation and addition onto proteins of negatively charged ADP-ribose polymers synthesized fro...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
SP Birkhäuser Verlag Basel
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955921/ https://www.ncbi.nlm.nih.gov/pubmed/20725763 http://dx.doi.org/10.1007/s00018-010-0490-8 |