Cargando…

P-Glycoprotein/MDR1 Regulates Pokemon Gene Transcription Through p53 Expression in Human Breast Cancer Cells

P-glycoprotein (Pgp), encoded by the multidrug resistance 1 (MDR1) gene, is an efflux transporter and plays an important role in pharmacokinetics. In this study, we demonstrated that the pokemon promoter activity, the pokemon mRNA and protein expression can be significantly inhibited by Pgp. Chromat...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Shengnan, Liu, Feng, Xie, Zhenhua, Zu, Xuyu, Xu, Wei, Jiang, Yuyang
Formato:	Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956079/ https://www.ncbi.nlm.nih.gov/pubmed/20957096 http://dx.doi.org/10.3390/ijms11093039

Ejemplares similares

Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression
por: Zu, Xuyu, et al.
Publicado: (2011)

p38β, A Novel Regulatory Target of Pokemon in Hepatic Cells
por: Chen, Zhe, et al.
Publicado: (2013)

Expression of MDR1/P glycoprotein in human sarcomas.
por: Vergier, B., et al.
Publicado: (1993)

Raltegravir does not revert efflux activity of MDR1-P-glycoprotein in human MDR cells
por: Dupuis, Maria Luisa, et al.
Publicado: (2013)

Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)-mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals
por: Zhou, Pengjun, et al.
Publicado: (2017)

Correction: Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)-mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals
por: Zhou, Pengjun, et al.
Publicado: (2021)

Pokemon Silencing Leads to Bim-Mediated Anoikis of Human Hepatoma Cell QGY7703
por: Liu, Kun, et al.
Publicado: (2012)

Inhibitory Effects of Neochamaejasmin B on P-Glycoprotein in MDCK-hMDR1 Cells and Molecular Docking of NCB Binding in P-Glycoprotein
por: Pan, Lanying, et al.
Publicado: (2015)

Going Forward with Pokemon Go
por: Chong, Yvette, et al.
Publicado: (2018)

Catalytic Transitions in the Human MDR1 P-Glycoprotein Drug Binding Sites
por: Wise, John G.
Publicado: (2012)

Determinants of intention to play Pokémon Go
por: Thongmak, Mathupayas
Publicado: (2020)

Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance
por: Surowiak, Pawel, et al.
Publicado: (2005)

HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein
por: Cianfriglia, Maurizio, et al.
Publicado: (2007)

The ‘Pokemon’ (ZBTB7) Gene: No Evidence of Association with Sporadic Breast Cancer
por: Salas, Antonio, et al.
Publicado: (2008)

p53 and P-glycoprotein are often co-expressed and are associated with poor prognosis in breast cancer.
por: Linn, S. C., et al.
Publicado: (1996)

Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells
por: Ding, Zhenyu, et al.
Publicado: (2010)

Pokemon Inhibits Transforming Growth Factor β-Smad4-Related Cell Proliferation Arrest in Breast Cancer through Specificity Protein 1
por: Chen, Ling, et al.
Publicado: (2019)

Global mapping of ZBTB7A transcription factor binding sites in HepG2 cells
por: Zu, Xuyu, et al.
Publicado: (2010)

Pokémon Go: cardiovascular benefit or injury risk?
por: Sharma, Pranev, et al.
Publicado: (2016)

On the Determinants and Outcomes of Passion for Playing Pokémon Go
por: Orosz, Gábor, et al.
Publicado: (2018)

Random forests, sound symbolism and Pokémon evolution
por: Kilpatrick, Alexander James, et al.
Publicado: (2023)

TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3β pathway and activation of caspases
por: Seo, Suk-Bin, et al.
Publicado: (2010)

Anlotinib Reverses Multidrug Resistance (MDR) in Osteosarcoma by Inhibiting P-Glycoprotein (PGP1) Function In Vitro and In Vivo
por: Wang, Gangyang, et al.
Publicado: (2022)

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein
por: Asperen, J van, et al.
Publicado: (1999)

Selective inhibition of MDR1 P-glycoprotein-mediated transport by the acridone carboxamide derivative GG918
por: Wallstab, A, et al.
Publicado: (1999)

Influence of RARα gene on MDR1 expression and P-glycoprotein function in human leukemic cells
por: Stromskaya, Tatjana P, et al.
Publicado: (2005)

Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA
por: Pluchino, Kristen M., et al.
Publicado: (2015)

Association between MDR1 gene of gastrointestinal tumors, the expression of P-glycoprotein and resistance to chemotherapeutic drugs
por: Su, Jian-Li, et al.
Publicado: (2017)

Quantitative Structure–Activity Relationships for the Flavonoid-Mediated Inhibition of P-Glycoprotein in KB/MDR1 Cells
por: Xia, Mengmeng, et al.
Publicado: (2019)

Emodin alleviates gemcitabine resistance in pancreatic cancer by inhibiting MDR1/P-glycoprotein and MRPs expression
por: Guo, Hongchun, et al.
Publicado: (2020)

Influence of Pokémon Go on Physical Activity: Study and Implications
por: Althoff, Tim, et al.
Publicado: (2016)

Pokémon GO and Physical Activity in Asia: Multilevel Study
por: Ma, Ben D, et al.
Publicado: (2018)

An Initial Evaluation of the Impact of Pokémon GO on Physical Activity
por: Xian, Ying, et al.
Publicado: (2017)

Eye problems and musculoskeletal pain in Pokémon Go players
por: Kaczmarek, Lukasz D., et al.
Publicado: (2022)

Playing Pokemon Go: Increased Life Satisfaction Through More (Positive) Social Interactions
por: Wingenbach, Tanja S. H., et al.
Publicado: (2022)

Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice
por: Brenn, Anja, et al.
Publicado: (2011)

P‐Glycoprotein Is Positively Correlated with p53 Protein Accumulation in Human Colorectal Cancers
por: Oka, Mikio, et al.
Publicado: (1997)

Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport
por: Sadiq, Muhammad Waqas, et al.
Publicado: (2015)

Pokémon GO Within the Context of Family Health: Retrospective Study
por: Militello, Lisa K, et al.
Publicado: (2018)

Correlates of excessive Pokemon Go playing among medical students
por: Ashar, Mili, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_sc020st0bo7vj1pg7mnargukv0