Context-Dependent Cell Cycle Checkpoint Abrogation by a Novel Kinase Inhibitor

BACKGROUND: Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of these kinases and utilized this molecule to probe the functional interplay between thes...

Descripción completa

Detalles Bibliográficos
Autores principales: Massey, Andrew J., Borgognoni, Jenifer, Bentley, Carol, Foloppe, Nicolas, Fiumana, Andrea, Walmsley, Lee
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956624/
https://www.ncbi.nlm.nih.gov/pubmed/20976184
http://dx.doi.org/10.1371/journal.pone.0013123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956624/
https://www.ncbi.nlm.nih.gov/pubmed/20976184
http://dx.doi.org/10.1371/journal.pone.0013123

Ejemplares similares