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Context-Dependent Cell Cycle Checkpoint Abrogation by a Novel Kinase Inhibitor

BACKGROUND: Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of these kinases and utilized this molecule to probe the functional interplay between thes...

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Detalles Bibliográficos
Autores principales:	Massey, Andrew J., Borgognoni, Jenifer, Bentley, Carol, Foloppe, Nicolas, Fiumana, Andrea, Walmsley, Lee
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956624/ https://www.ncbi.nlm.nih.gov/pubmed/20976184 http://dx.doi.org/10.1371/journal.pone.0013123

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