Cargando…

Context-Dependent Cell Cycle Checkpoint Abrogation by a Novel Kinase Inhibitor

BACKGROUND: Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of these kinases and utilized this molecule to probe the functional interplay between thes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Massey, Andrew J., Borgognoni, Jenifer, Bentley, Carol, Foloppe, Nicolas, Fiumana, Andrea, Walmsley, Lee
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956624/ https://www.ncbi.nlm.nih.gov/pubmed/20976184 http://dx.doi.org/10.1371/journal.pone.0013123

Ejemplares similares

G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer
por: Bucher, N, et al.
Publicado: (2008)

Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design
por: Massey, Andrew J., et al.
Publicado: (2015)

OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases
por: Ji, Wenbin, et al.
Publicado: (2016)

DNA breakage and cell cycle checkpoint abrogation induced by a therapeutic thiopurine and UVA radiation
por: Brem, Reto, et al.
Publicado: (2010)

CKAP4 and mutant p53 cooperatively abrogate cell cycle checkpoint to induce genotoxic resistance in ovarian cancer
por: Huang, Canhua, et al.
Publicado: (2023)

Advantages of Tyrosine Kinase Anti-Angiogenic Cediranib over Bevacizumab: Cell Cycle Abrogation and Synergy with Chemotherapy
por: Bi, Jianling, et al.
Publicado: (2021)

BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors
por: Bertran-Alamillo, Jordi, et al.
Publicado: (2023)

Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe
por: Cornago, M, et al.
Publicado: (2014)

Myt1 overexpression mediates resistance to cell cycle and DNA damage checkpoint kinase inhibitors
por: Sokhi, Sargun, et al.
Publicado: (2023)

KLHL29-mediated DDX3X degradation promotes chemosensitivity by abrogating cell cycle checkpoint in triple-negative breast cancer
por: Yao, Litong, et al.
Publicado: (2023)

The cell cycle checkpoint inhibitors in the treatment of leukemias
por: Ghelli Luserna di Rora’, A., et al.
Publicado: (2017)

Review of the Immune Checkpoint Inhibitors in the Context of Cancer Treatment
por: Alturki, Norah A.
Publicado: (2023)

Understanding the Sequence-Dependence of DNA Groove Dimensions: Implications for DNA Interactions
por: Oguey, Christophe, et al.
Publicado: (2010)

Nek family of kinases in cell cycle, checkpoint control and cancer
por: Moniz, Larissa, et al.
Publicado: (2011)

Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors
por: Faes, Seraina, et al.
Publicado: (2016)

Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice
por: Siaw, Joachim T., et al.
Publicado: (2016)

Transarterial Chemoembolization Combined with Immune Checkpoint Inhibitors Plus Tyrosine Kinase Inhibitors versus Immune Checkpoint Inhibitors Plus Tyrosine Kinase Inhibitors for Advanced Hepatocellular Carcinoma
por: Huang, Jin-Tao, et al.
Publicado: (2022)

Chemotherapy-induced recruitment of myeloid-derived suppressor cells abrogates efficacy of immune checkpoint blockade
por: Kwong, Tsz Tung, et al.
Publicado: (2020)

Combining PEGylated mito-atovaquone with MCT and Krebs cycle redox inhibitors as a potential strategy to abrogate tumor cell proliferation
por: Cheng, Gang, et al.
Publicado: (2022)

A bioavailable cathepsin S nitrile inhibitor abrogates tumor development
por: Wilkinson, Richard D. A., et al.
Publicado: (2016)

Genetic abrogation of immune checkpoints in antigen-specific cytotoxic T-lymphocyte as a potential alternative to blockade immunotherapy
por: Zhang, Chi, et al.
Publicado: (2018)

G2/M Checkpoint Abrogation With Selective Inhibitors Results in Increased Chromatid Breaks and Radiosensitization of 82-6 hTERT and RPE Human Cells
por: Nikolakopoulou, Aggeliki, et al.
Publicado: (2021)

The Role of the Lymphocyte Functional Crosstalk and Regulation in the Context of Checkpoint Inhibitor Treatment—Review
por: Seliger, Barbara
Publicado: (2019)

Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1
por: Imbert, Caroline, et al.
Publicado: (2020)

Regulator of chromatin condensation 1 abrogates the G1 cell cycle checkpoint via Cdk1 in human papillomavirus E7-expressing epithelium and cervical cancer cells
por: Qiao, Lijun, et al.
Publicado: (2018)

Dose Dependent Effects on Cell Cycle Checkpoints and DNA Repair by Bendamustine
por: Beeharry, Neil, et al.
Publicado: (2012)

Inhibition of the checkpoint kinase Chk1 induces DNA damage and cell death in human Leukemia and Lymphoma cells
por: Bryant, Christopher, et al.
Publicado: (2014)

Small-molecule survivin inhibitor YM155 enhances radiosensitization in esophageal squamous cell carcinoma by the abrogation of G(2) checkpoint and suppression of homologous recombination repair
por: Qin, Qin, et al.
Publicado: (2014)

Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival
por: Thornton, Tina M., et al.
Publicado: (2008)

Targeting Cell Cycle Checkpoint Kinases to Overcome Intrinsic Radioresistance in Brain Tumor Cells
por: Vlatkovic, Tijana, et al.
Publicado: (2022)

Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters
por: Sheu, Yi-Jun, et al.
Publicado: (2022)

Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness
por: Oropeza, Elena, et al.
Publicado: (2023)

Cyclin-Dependent Kinase 4 and 6 Inhibitors in Cell Cycle Dysregulation for Breast Cancer Treatment
por: Susanti, Ni Made Pitri, et al.
Publicado: (2021)

Clinical Potential of Kinase Inhibitors in Combination with Immune Checkpoint Inhibitors for the Treatment of Solid Tumors
por: Ahn, Ryuhjin, et al.
Publicado: (2021)

Anti–Interleukin-6 and Janus Kinase Inhibitors for Severe Neurologic Toxicity of Checkpoint Inhibitors
por: Picca, Alberto, et al.
Publicado: (2021)

Small cell carcinoma of the kidney treated with immune checkpoint inhibitor/tyrosine kinase inhibitor
por: Harada, Mirii, et al.
Publicado: (2023)

Caspase-10-Dependent Cell Death in Fas/CD95 Signalling Is Not Abrogated by Caspase Inhibitor zVAD-fmk
por: Lafont, Elodie, et al.
Publicado: (2010)

Co-targeting aurora kinase with PD-L1 and PI3K abrogates immune checkpoint mediated proliferation in peripheral T-cell lymphoma: a novel therapeutic strategy
por: Islam, Shariful, et al.
Publicado: (2017)

Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer
por: Liu, Shuying, et al.
Publicado: (2014)

Sodium butyrate enhances the cytotoxic effect of cisplatin by abrogating the cisplatin imposed cell cycle arrest
por: Koprinarova, Miglena, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_pbv9ojkm6bf63g3li45rauf175