Activation of PPARs α, β/δ, and γ Impairs TGF-β1-Induced Collagens' Production and Modulates the TIMP-1/MMPs Balance in Three-Dimensional Cultured Chondrocytes

Background and Purpose. We investigated the potency of Peroxisome Proliferators-Activated Receptors (PPARs) α, β/δ, and γ agonists to modulate Transforming Growth Factor-β1 (TGF-β1-) induced collagen production or changes in Tissue Inhibitor of Matrix Metalloproteinase- (TIMP-) 1/Matrix Metalloprote...

Descripción completa

Detalles Bibliográficos
Autores principales: Poleni, Paul-Emile, Etienne, Stephanie, Velot, Emilie, Netter, Patrick, Bianchi, Arnaud
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957135/
https://www.ncbi.nlm.nih.gov/pubmed/20981144
http://dx.doi.org/10.1155/2010/635912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957135/
https://www.ncbi.nlm.nih.gov/pubmed/20981144
http://dx.doi.org/10.1155/2010/635912

Ejemplares similares