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Activation of PPARs α, β/δ, and γ Impairs TGF-β1-Induced Collagens' Production and Modulates the TIMP-1/MMPs Balance in Three-Dimensional Cultured Chondrocytes

Background and Purpose. We investigated the potency of Peroxisome Proliferators-Activated Receptors (PPARs) α, β/δ, and γ agonists to modulate Transforming Growth Factor-β1 (TGF-β1-) induced collagen production or changes in Tissue Inhibitor of Matrix Metalloproteinase- (TIMP-) 1/Matrix Metalloprote...

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Detalles Bibliográficos
Autores principales:	Poleni, Paul-Emile, Etienne, Stephanie, Velot, Emilie, Netter, Patrick, Bianchi, Arnaud
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957135/ https://www.ncbi.nlm.nih.gov/pubmed/20981144 http://dx.doi.org/10.1155/2010/635912

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