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Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCδ proteolytic activation and mitochondrial translocation
Emerging evidence implicates impaired protein degradation by the ubiquitin proteasome system (UPS) in Parkinson's disease; however cellular mechanisms underlying dopaminergic degeneration during proteasomal dysfunction are yet to be characterized. In the present study, we identified that the no...
Autores principales: | Sun, Faneng, Kanthasamy, Arthi, Song, Chunjuan, Yang, Yongjie, Anantharam, Vellareddy, Kanthasamy, Anumantha G |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957660/ https://www.ncbi.nlm.nih.gov/pubmed/18298651 http://dx.doi.org/10.1111/j.1582-4934.2008.00293.x |
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