Evaluation of Computational Docking to Identify Pregnane X Receptor Agonists in the ToxCast Database

BACKGROUND: The pregnane X receptor (PXR) is a key transcriptional regulator of many genes [e.g., cytochrome P450s (CYP2C9, CYP3A4, CYP2B6), MDR1] involved in xenobiotic metabolism and excretion. OBJECTIVES: As part of an evaluation of different approaches to predict compound affinity for nuclear ho...

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Detalles Bibliográficos
Autores principales: Kortagere, Sandhya, Krasowski, Matthew D., Reschly, Erica J., Venkatesh, Madhukumar, Mani, Sridhar, Ekins, Sean
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957921/
https://www.ncbi.nlm.nih.gov/pubmed/20558333
http://dx.doi.org/10.1289/ehp.1001930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957921/
https://www.ncbi.nlm.nih.gov/pubmed/20558333
http://dx.doi.org/10.1289/ehp.1001930

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