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Evaluation of Computational Docking to Identify Pregnane X Receptor Agonists in the ToxCast Database

BACKGROUND: The pregnane X receptor (PXR) is a key transcriptional regulator of many genes [e.g., cytochrome P450s (CYP2C9, CYP3A4, CYP2B6), MDR1] involved in xenobiotic metabolism and excretion. OBJECTIVES: As part of an evaluation of different approaches to predict compound affinity for nuclear ho...

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Detalles Bibliográficos
Autores principales:	Kortagere, Sandhya, Krasowski, Matthew D., Reschly, Erica J., Venkatesh, Madhukumar, Mani, Sridhar, Ekins, Sean
Formato:	Texto
Lenguaje:	English
Publicado:	National Institute of Environmental Health Sciences 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957921/ https://www.ncbi.nlm.nih.gov/pubmed/20558333 http://dx.doi.org/10.1289/ehp.1001930

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