Murine Lupus Susceptibility Locus Sle1a Requires the Expression of two Subloci to Induce Inflammatory T Cells

The NZM2410-derived Sle1a lupus susceptibility locus induces activated autoreactive CD4(+) T cells and reduces the number and function of Foxp3(+) regulatory T cells. In this study, we first showed that Sle1a contributes to autoimmunity by increasing anti-nuclear antibody production when expressed o...

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Detalles Bibliográficos
Autores principales: Cuda, Carla M., Zeumer, Leilani, Sobel, Eric S., Croker, Byron P., Morel, Laurence
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958247/
https://www.ncbi.nlm.nih.gov/pubmed/20445563
http://dx.doi.org/10.1038/gene.2010.23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958247/
https://www.ncbi.nlm.nih.gov/pubmed/20445563
http://dx.doi.org/10.1038/gene.2010.23

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