The cytosolic exonuclease TREX1 inhibits the innate immune response to HIV-1

Viral infection triggers innate immune sensors to produce type I interferons (IFN). However, HIV infection of T cells and macrophages does not trip these alarms. How HIV avoids activating nucleic acid sensors is unknown. The cytosolic exonuclease TREX1 suppressed IFN triggered by HIV. In Trex1(−/−)...

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Detalles Bibliográficos
Autores principales: Yan, Nan, Regalado-Magdos, Ashton D., Stiggelbout, Bart, Lee-Kirsch, Min Ae, Lieberman, Judy
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958248/
https://www.ncbi.nlm.nih.gov/pubmed/20871604
http://dx.doi.org/10.1038/ni.1941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958248/
https://www.ncbi.nlm.nih.gov/pubmed/20871604
http://dx.doi.org/10.1038/ni.1941

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