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The cytosolic exonuclease TREX1 inhibits the innate immune response to HIV-1
Viral infection triggers innate immune sensors to produce type I interferons (IFN). However, HIV infection of T cells and macrophages does not trip these alarms. How HIV avoids activating nucleic acid sensors is unknown. The cytosolic exonuclease TREX1 suppressed IFN triggered by HIV. In Trex1(−/−)...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958248/ https://www.ncbi.nlm.nih.gov/pubmed/20871604 http://dx.doi.org/10.1038/ni.1941 |