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S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and regulatory T cells
Naïve CD4(+) T cells differentiate into diverse effector and regulatory lineages to orchestrate immunity and tolerance. The differentiation of pro-inflammatory T(H)1 and anti-inflammatory Foxp3+ regulatory T cells (Treg) was reciprocally regulated by S1P(1), a receptor for the bioactive lipid sphing...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958252/ https://www.ncbi.nlm.nih.gov/pubmed/20852647 http://dx.doi.org/10.1038/ni.1939 |