Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

Faithful DNA replication is essential to all life. Hydroxyurea (HU) depletes the cells of dNTPs, which initially results in stalled replication forks that, after prolonged treatment, collapse into DSBs. Here, we report that stalled replication forks are efficiently restarted in a RAD51-dependent pro...

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Detalles Bibliográficos
Autores principales: Petermann, Eva, Orta, Manuel Luís, Issaeva, Natalia, Schultz, Niklas, Helleday, Thomas
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958316/
https://www.ncbi.nlm.nih.gov/pubmed/20188668
http://dx.doi.org/10.1016/j.molcel.2010.01.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958316/
https://www.ncbi.nlm.nih.gov/pubmed/20188668
http://dx.doi.org/10.1016/j.molcel.2010.01.021

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