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Release of Mps1 from kinetochores is crucial for timely anaphase onset

Mps1 kinase activity is required for proper chromosome segregation during mitosis through its involvements in microtubule–chromosome attachment error correction and the mitotic checkpoint. Mps1 dynamically exchanges on unattached kinetochores but is largely removed from kinetochores in metaphase. He...

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Detalles Bibliográficos
Autores principales: Jelluma, Nannette, Dansen, Tobias B., Sliedrecht, Tale, Kwiatkowski, Nicholas P., Kops, Geert J.P.L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958484/
https://www.ncbi.nlm.nih.gov/pubmed/20937696
http://dx.doi.org/10.1083/jcb.201003038