Pervasive Cryptic Epistasis in Molecular Evolution

The functional effects of most amino acid replacements accumulated during molecular evolution are unknown, because most are not observed naturally and the possible combinations are too numerous. We created 168 single mutations in wild-type Escherichia coli isopropymalate dehydrogenase (IMDH) that ma...

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Detalles Bibliográficos
Autores principales: Lunzer, Mark, Golding, G. Brian, Dean, Antony M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958800/
https://www.ncbi.nlm.nih.gov/pubmed/20975933
http://dx.doi.org/10.1371/journal.pgen.1001162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958800/
https://www.ncbi.nlm.nih.gov/pubmed/20975933
http://dx.doi.org/10.1371/journal.pgen.1001162

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