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In Vitro and In Vivo Studies Identify Important Features of Dengue Virus pr-E Protein Interactions

Flaviviruses bud into the endoplasmic reticulum and are transported through the secretory pathway, where the mildly acidic environment triggers particle rearrangement and allows furin processing of the prM protein to pr and M. The peripheral pr peptide remains bound to virus at low pH and inhibits v...

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Detalles Bibliográficos
Autores principales: Zheng, Aihua, Umashankar, Mahadevaiah, Kielian, Margaret
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958806/
https://www.ncbi.nlm.nih.gov/pubmed/20975939
http://dx.doi.org/10.1371/journal.ppat.1001157