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In Vitro and In Vivo Studies Identify Important Features of Dengue Virus pr-E Protein Interactions
Flaviviruses bud into the endoplasmic reticulum and are transported through the secretory pathway, where the mildly acidic environment triggers particle rearrangement and allows furin processing of the prM protein to pr and M. The peripheral pr peptide remains bound to virus at low pH and inhibits v...
Autores principales: | Zheng, Aihua, Umashankar, Mahadevaiah, Kielian, Margaret |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958806/ https://www.ncbi.nlm.nih.gov/pubmed/20975939 http://dx.doi.org/10.1371/journal.ppat.1001157 |
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