Ancient and Recent Adaptive Evolution of Primate Non-Homologous End Joining Genes

In human cells, DNA double-strand breaks are repaired primarily by the non-homologous end joining (NHEJ) pathway. Given their critical nature, we expected NHEJ proteins to be evolutionarily conserved, with relatively little sequence change over time. Here, we report that while critical domains of th...

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Detalles Bibliográficos
Autores principales: Demogines, Ann, East, Alysia M., Lee, Ji-Hoon, Grossman, Sharon R., Sabeti, Pardis C., Paull, Tanya T., Sawyer, Sara L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958818/
https://www.ncbi.nlm.nih.gov/pubmed/20975951
http://dx.doi.org/10.1371/journal.pgen.1001169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958818/
https://www.ncbi.nlm.nih.gov/pubmed/20975951
http://dx.doi.org/10.1371/journal.pgen.1001169

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