Mutation of Ser172 in Yeast β Tubulin Induces Defects in Microtubule Dynamics and Cell Division

Ser172 of β tubulin is an important residue that is mutated in a human brain disease and phosphorylated by the cyclin-dependent kinase Cdk1 in mammalian cells. To examine the role of this residue, we used the yeast S. cerevisiae as a model and produced two different mutations (S172A and S172E) of th...

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Detalles Bibliográficos
Autores principales: Caudron, Fabrice, Denarier, Eric, Thibout-Quintana, Jenny-Constanza, Brocard, Jacques, Andrieux, Annie, Fourest-Lieuvin, Anne
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958848/
https://www.ncbi.nlm.nih.gov/pubmed/21042413
http://dx.doi.org/10.1371/journal.pone.0013553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958848/
https://www.ncbi.nlm.nih.gov/pubmed/21042413
http://dx.doi.org/10.1371/journal.pone.0013553

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