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Mutation of Ser172 in Yeast β Tubulin Induces Defects in Microtubule Dynamics and Cell Division
Ser172 of β tubulin is an important residue that is mutated in a human brain disease and phosphorylated by the cyclin-dependent kinase Cdk1 in mammalian cells. To examine the role of this residue, we used the yeast S. cerevisiae as a model and produced two different mutations (S172A and S172E) of th...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958848/ https://www.ncbi.nlm.nih.gov/pubmed/21042413 http://dx.doi.org/10.1371/journal.pone.0013553 |