Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes

BACKGROUND: The classic neuritic β-amyloid plaque of Alzheimer's disease (AD) is typically associated with activated microglia and neuroinflammation. Similarly, cerebrovascular β-amyloid (Aβ) deposits are surrounded by perivascular macrophages. Both observations indicate a contribution of the m...

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Detalles Bibliográficos
Autores principales: Spitzer, Philipp, Herrmann, Martin, Klafki, Hans-Wolfgang, Smirnov, Alexander, Lewczuk, Piotr, Kornhuber, Johannes, Wiltfang, Jens, Maler, Juan Manuel
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958903/
https://www.ncbi.nlm.nih.gov/pubmed/20929546
http://dx.doi.org/10.1186/1742-2094-7-59

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958903/
https://www.ncbi.nlm.nih.gov/pubmed/20929546
http://dx.doi.org/10.1186/1742-2094-7-59

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