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S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)
BACKGROUND: S110 is a novel dinucleoside analog that could have advantages over existing DNA methyltransferase (DNMT) inhibitors such as decitabine. A potential therapeutic role for S110 is to increase fetal hemoglobin (HbF) levels to treat β-hemoglobinopathies. In these experiments the effect of S1...
Autores principales: | , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958909/ https://www.ncbi.nlm.nih.gov/pubmed/20932295 http://dx.doi.org/10.1186/1479-5876-8-92 |