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S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)

BACKGROUND: S110 is a novel dinucleoside analog that could have advantages over existing DNA methyltransferase (DNMT) inhibitors such as decitabine. A potential therapeutic role for S110 is to increase fetal hemoglobin (HbF) levels to treat β-hemoglobinopathies. In these experiments the effect of S1...

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Detalles Bibliográficos
Autores principales:	Lavelle, Donald, Saunthararajah, Yogen, Vaitkus, Kestis, Singh, Mahipal, Banzon, Virryan, Phiasivongsva, Pasit, Redkar, Sanjeev, Kanekal, Sarath, Bearss, David, Shi, Chongtie, Inloes, Roger, DeSimone, Joseph
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958909/ https://www.ncbi.nlm.nih.gov/pubmed/20932295 http://dx.doi.org/10.1186/1479-5876-8-92

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