Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells

BACKGROUND: Hyperactivity of the epithelial sodium (Na(+)) channel (ENaC) and increased Na(+ )absorption by airway epithelial cells leading to airway surface liquid dehydration and impaired mucociliary clearance are thought to play an important role in the pathogenesis of cystic fibrosis (CF) pulmon...

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Detalles Bibliográficos
Autores principales: Prulière-Escabasse, Virginie, Clerici, Christine, Vuagniaux, Grégoire, Coste, Andre, Escudier, Estelle, Planès, Carole
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959028/
https://www.ncbi.nlm.nih.gov/pubmed/20932306
http://dx.doi.org/10.1186/1465-9921-11-141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959028/
https://www.ncbi.nlm.nih.gov/pubmed/20932306
http://dx.doi.org/10.1186/1465-9921-11-141

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