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Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells
BACKGROUND: Hyperactivity of the epithelial sodium (Na(+)) channel (ENaC) and increased Na(+ )absorption by airway epithelial cells leading to airway surface liquid dehydration and impaired mucociliary clearance are thought to play an important role in the pathogenesis of cystic fibrosis (CF) pulmon...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959028/ https://www.ncbi.nlm.nih.gov/pubmed/20932306 http://dx.doi.org/10.1186/1465-9921-11-141 |