Molecular determinants of improved cathepsin B inhibition by new cystatins obtained by DNA shuffling

BACKGROUND: Cystatins are inhibitors of cysteine proteases. The majority are only weak inhibitors of human cathepsin B, which has been associated with cancer, Alzheimer's disease and arthritis. RESULTS: Starting from the sequences of oryzacystatin-1 and canecystatin-1, a shuffling library was d...

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Detalles Bibliográficos
Autores principales: Valadares, Napoleão F, Dellamano, Márcia, Soares-Costa, Andrea, Henrique-Silva, Flávio, Garratt, Richard C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959088/
https://www.ncbi.nlm.nih.gov/pubmed/20920298
http://dx.doi.org/10.1186/1472-6807-10-30

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959088/
https://www.ncbi.nlm.nih.gov/pubmed/20920298
http://dx.doi.org/10.1186/1472-6807-10-30

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