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Molecular determinants of improved cathepsin B inhibition by new cystatins obtained by DNA shuffling
BACKGROUND: Cystatins are inhibitors of cysteine proteases. The majority are only weak inhibitors of human cathepsin B, which has been associated with cancer, Alzheimer's disease and arthritis. RESULTS: Starting from the sequences of oryzacystatin-1 and canecystatin-1, a shuffling library was d...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959088/ https://www.ncbi.nlm.nih.gov/pubmed/20920298 http://dx.doi.org/10.1186/1472-6807-10-30 |