A Toll-Like Receptor-Responsive Kinase, Protein Kinase R, Is Inactivated in Endotoxin Tolerance through Differential K63/K48 Ubiquitination

Overwhelming inflammation triggered by systemic infection in bacterial sepsis contributes to the pathology of this condition. Toll-like receptors (TLRs) are important in early septic inflammation. As a safeguard, the innate immune system has evolved to counter excessive inflammation through the indu...

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Detalles Bibliográficos
Autores principales: Perkins, Darren J., Qureshi, Nilofer, Vogel, Stefanie N.
Formato: Texto
Lenguaje:English
Publicado: American Society of Microbiology 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962435/
https://www.ncbi.nlm.nih.gov/pubmed/20978539
http://dx.doi.org/10.1128/mBio.00239-10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962435/
https://www.ncbi.nlm.nih.gov/pubmed/20978539
http://dx.doi.org/10.1128/mBio.00239-10

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