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Aging of Xenopus tropicalis Eggs Leads to Deadenylation of a Specific Set of Maternal mRNAs and Loss of Developmental Potential

As first shown more than 100 years ago, fertilization of an aged (overripe) egg increases the rate of malformations and embryonic loss in several vertebrates, including possibly humans as well. Since the molecular events in aging eggs may be similar in these species, we established in the frog Xenop...

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Detalles Bibliográficos
Autores principales: Kosubek, Anna, Klein-Hitpass, Ludger, Rademacher, Katrin, Horsthemke, Bernhard, Ryffel, Gerhart U.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962626/
https://www.ncbi.nlm.nih.gov/pubmed/21042572
http://dx.doi.org/10.1371/journal.pone.0013532