Non-Synonymous and Synonymous Coding SNPs Show Similar Likelihood and Effect Size of Human Disease Association

Many DNA variants have been identified on more than 300 diseases and traits using Genome-Wide Association Studies (GWASs). Some have been validated using deep sequencing, but many fewer have been validated functionally, primarily focused on non-synonymous coding SNPs (nsSNPs). It is an open question...

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Detalles Bibliográficos
Autores principales: Chen, Rong, Davydov, Eugene V., Sirota, Marina, Butte, Atul J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962641/
https://www.ncbi.nlm.nih.gov/pubmed/21042586
http://dx.doi.org/10.1371/journal.pone.0013574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962641/
https://www.ncbi.nlm.nih.gov/pubmed/21042586
http://dx.doi.org/10.1371/journal.pone.0013574

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