Molecular Mapping of the RNA Cap 2′-O-Methyltransferase Activation Interface between Severe Acute Respiratory Syndrome Coronavirus nsp10 and nsp16

Several protein-protein interactions within the SARS-CoV proteome have been identified, one of them being between non-structural proteins nsp10 and nsp16. In this work, we have mapped key residues on the nsp10 surface involved in this interaction. Alanine-scanning mutagenesis, bioinformatics, and mo...

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Detalles Bibliográficos
Autores principales: Lugari, Adrien, Betzi, Stephane, Decroly, Etienne, Bonnaud, Emmanuel, Hermant, Aurélie, Guillemot, Jean-Claude, Debarnot, Claire, Borg, Jean-Paul, Bouvet, Mickaël, Canard, Bruno, Morelli, Xavier, Lécine, Patrick
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963367/
https://www.ncbi.nlm.nih.gov/pubmed/20699222
http://dx.doi.org/10.1074/jbc.M110.120014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963367/
https://www.ncbi.nlm.nih.gov/pubmed/20699222
http://dx.doi.org/10.1074/jbc.M110.120014

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