SIRT1 Activation by Small Molecules: KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR

SIRT1 is a protein deacetylase that has emerged as a therapeutic target for the development of activators to treat diseases of aging. SIRT1-activating compounds (STACs) have been developed that produce biological effects consistent with direct SIRT1 activation. At the molecular level, the mechanism...

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Detalles Bibliográficos
Autores principales: Dai, Han, Kustigian, Lauren, Carney, David, Case, April, Considine, Thomas, Hubbard, Basil P., Perni, Robert B., Riera, Thomas V., Szczepankiewicz, Bruce, Vlasuk, George P., Stein, Ross L.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963390/
https://www.ncbi.nlm.nih.gov/pubmed/20702418
http://dx.doi.org/10.1074/jbc.M110.133892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963390/
https://www.ncbi.nlm.nih.gov/pubmed/20702418
http://dx.doi.org/10.1074/jbc.M110.133892

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