The Viral Oncoprotein Tax Sequesters DNA Damage Response Factors by Tethering MDC1 to Chromatin

Infection with human T-cell leukemia virus induces cellular genomic instability mediated through the viral oncoprotein Tax. Here we present evidence that Tax undermines the cellular DNA damage response by sequestration of damage response factors. We show by confocal microscopy that Tax forms damage-...

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Detalles Bibliográficos
Autores principales: Belgnaoui, S. Mehdi, Fryrear, Kimberly A., Nyalwidhe, Julius O., Guo, Xin, Semmes, O. John
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963403/
https://www.ncbi.nlm.nih.gov/pubmed/20729195
http://dx.doi.org/10.1074/jbc.M110.146373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963403/
https://www.ncbi.nlm.nih.gov/pubmed/20729195
http://dx.doi.org/10.1074/jbc.M110.146373

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