Pparg-P465L Mutation Worsens Hyperglycemia in Ins2-Akita Female Mice via Adipose-Specific Insulin Resistance and Storage Dysfunction

OBJECTIVE: The dominant-negative P467L mutation in peroxisome proliferator activated receptor-γ (PPARγ) was identified in insulin-resistant patients with hyperglycemia and lipodystrophy. In contrast, mice carrying the corresponding Pparg-P465L mutation have normal insulin sensitivity, with mild hype...

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Detalles Bibliográficos
Autores principales: Pendse, Avani A., Johnson, Lance A., Tsai, Yau-Sheng, Maeda, Nobuyo
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Pathophysiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963548/
https://www.ncbi.nlm.nih.gov/pubmed/20724579
http://dx.doi.org/10.2337/db10-0673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963548/
https://www.ncbi.nlm.nih.gov/pubmed/20724579
http://dx.doi.org/10.2337/db10-0673

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