α-Helix peptides designed from EBV-gH protein display higher antigenicity and induction of monocyte apoptosis than the native peptide

We tested the hypothesis that stabilizing α-helix of Epstein–Barr virus gH-derived peptide 11438 used for binding human cells will increase its biological activity. Non-stable α-helix of peptide 11438 was unfolded in an entropy-driven process, despite the opposing effect of the enthalpy factor. Addi...

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Detalles Bibliográficos
Autores principales: Urquiza, Mauricio, Melo-Cardenas, Johanna, Guevara, Tatiana, Echeverria, Ignacia, Rodriguez, Isabel C., Vanegas, Magnolia, Amzel, Mario, Patarroyo, Manuel E.
Formato: Texto
Lenguaje:English
Publicado: Springer Vienna 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963735/
https://www.ncbi.nlm.nih.gov/pubmed/20473772
http://dx.doi.org/10.1007/s00726-010-0620-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963735/
https://www.ncbi.nlm.nih.gov/pubmed/20473772
http://dx.doi.org/10.1007/s00726-010-0620-5

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