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Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease

Gluten proteins from wheat can induce celiac disease (CD) in genetically susceptible individuals. Specific gluten peptides can be presented by antigen presenting cells to gluten-sensitive T-cell lymphocytes leading to CD. During the last decades, a significant increase has been observed in the preva...

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Autores principales: van den Broeck, Hetty C., de Jong, Hein C., Salentijn, Elma M. J., Dekking, Liesbeth, Bosch, Dirk, Hamer, Rob J., Gilissen, Ludovicus J. W. J., van der Meer, Ingrid M., Smulders, Marinus J. M.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963738/
https://www.ncbi.nlm.nih.gov/pubmed/20664999
http://dx.doi.org/10.1007/s00122-010-1408-4
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author van den Broeck, Hetty C.
de Jong, Hein C.
Salentijn, Elma M. J.
Dekking, Liesbeth
Bosch, Dirk
Hamer, Rob J.
Gilissen, Ludovicus J. W. J.
van der Meer, Ingrid M.
Smulders, Marinus J. M.
author_facet van den Broeck, Hetty C.
de Jong, Hein C.
Salentijn, Elma M. J.
Dekking, Liesbeth
Bosch, Dirk
Hamer, Rob J.
Gilissen, Ludovicus J. W. J.
van der Meer, Ingrid M.
Smulders, Marinus J. M.
author_sort van den Broeck, Hetty C.
collection PubMed
description Gluten proteins from wheat can induce celiac disease (CD) in genetically susceptible individuals. Specific gluten peptides can be presented by antigen presenting cells to gluten-sensitive T-cell lymphocytes leading to CD. During the last decades, a significant increase has been observed in the prevalence of CD. This may partly be attributed to an increase in awareness and to improved diagnostic techniques, but increased wheat and gluten consumption is also considered a major cause. To analyze whether wheat breeding contributed to the increase of the prevalence of CD, we have compared the genetic diversity of gluten proteins for the presence of two CD epitopes (Glia-α9 and Glia-α20) in 36 modern European wheat varieties and in 50 landraces representing the wheat varieties grown up to around a century ago. Glia-α9 is a major (immunodominant) epitope that is recognized by the majority of CD patients. The minor Glia-α20 was included as a technical reference. Overall, the presence of the Glia-α9 epitope was higher in the modern varieties, whereas the presence of the Glia-α20 epitope was lower, as compared to the landraces. This suggests that modern wheat breeding practices may have led to an increased exposure to CD epitopes. On the other hand, some modern varieties and landraces have been identified that have relatively low contents of both epitopes. Such selected lines may serve as a start to breed wheat for the introduction of ‘low CD toxic’ as a new breeding trait. Large-scale culture and consumption of such varieties would considerably aid in decreasing the prevalence of CD.
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spelling pubmed-29637382010-11-16 Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease van den Broeck, Hetty C. de Jong, Hein C. Salentijn, Elma M. J. Dekking, Liesbeth Bosch, Dirk Hamer, Rob J. Gilissen, Ludovicus J. W. J. van der Meer, Ingrid M. Smulders, Marinus J. M. Theor Appl Genet Original Paper Gluten proteins from wheat can induce celiac disease (CD) in genetically susceptible individuals. Specific gluten peptides can be presented by antigen presenting cells to gluten-sensitive T-cell lymphocytes leading to CD. During the last decades, a significant increase has been observed in the prevalence of CD. This may partly be attributed to an increase in awareness and to improved diagnostic techniques, but increased wheat and gluten consumption is also considered a major cause. To analyze whether wheat breeding contributed to the increase of the prevalence of CD, we have compared the genetic diversity of gluten proteins for the presence of two CD epitopes (Glia-α9 and Glia-α20) in 36 modern European wheat varieties and in 50 landraces representing the wheat varieties grown up to around a century ago. Glia-α9 is a major (immunodominant) epitope that is recognized by the majority of CD patients. The minor Glia-α20 was included as a technical reference. Overall, the presence of the Glia-α9 epitope was higher in the modern varieties, whereas the presence of the Glia-α20 epitope was lower, as compared to the landraces. This suggests that modern wheat breeding practices may have led to an increased exposure to CD epitopes. On the other hand, some modern varieties and landraces have been identified that have relatively low contents of both epitopes. Such selected lines may serve as a start to breed wheat for the introduction of ‘low CD toxic’ as a new breeding trait. Large-scale culture and consumption of such varieties would considerably aid in decreasing the prevalence of CD. Springer-Verlag 2010-07-28 2010 /pmc/articles/PMC2963738/ /pubmed/20664999 http://dx.doi.org/10.1007/s00122-010-1408-4 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Paper
van den Broeck, Hetty C.
de Jong, Hein C.
Salentijn, Elma M. J.
Dekking, Liesbeth
Bosch, Dirk
Hamer, Rob J.
Gilissen, Ludovicus J. W. J.
van der Meer, Ingrid M.
Smulders, Marinus J. M.
Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease
title Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease
title_full Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease
title_fullStr Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease
title_full_unstemmed Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease
title_short Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease
title_sort presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963738/
https://www.ncbi.nlm.nih.gov/pubmed/20664999
http://dx.doi.org/10.1007/s00122-010-1408-4
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