Cargando…

Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells

Retinal pigment epithelial (RPE) cells are continually exposed to oxidative stress that contributes to protein misfolding, aggregation and functional abnormalities during aging. The protein aggregates formed at the cell periphery are delivered along the microtubulus network by dynein-dependent retro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ryhänen, Tuomas, Viiri, Johanna, Hyttinen, Juha M. T., Uusitalo, Hannu, Salminen, Antero, Kaarniranta, Kai
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963810/ https://www.ncbi.nlm.nih.gov/pubmed/20981255 http://dx.doi.org/10.1155/2011/798052

Ejemplares similares

Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells
por: Ryhänen, Tuomas, et al.
Publicado: (2009)

p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells
por: Viiri, Johanna, et al.
Publicado: (2010)

Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells
por: Juuti-Uusitalo, Kati, et al.
Publicado: (2017)

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan
por: Salminen, Antero, et al.
Publicado: (2011)

The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells
por: Paimela, Tuomas, et al.
Publicado: (2012)

Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process
por: Salminen, Antero, et al.
Publicado: (2012)

Efflux Protein Expression in Human Stem Cell-Derived Retinal Pigment Epithelial Cells
por: Juuti-Uusitalo, Kati, et al.
Publicado: (2012)

The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology
por: Hyttinen, Juha M. T., et al.
Publicado: (2019)

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells
por: Viiri, Johanna, et al.
Publicado: (2013)

Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro
por: Viiri, J., et al.
Publicado: (2009)

Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration
por: Kaarniranta, Kai, et al.
Publicado: (2020)

Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α(-/-) Mouse Model
por: Sridevi Gurubaran, Iswariyaraja, et al.
Publicado: (2020)

Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells
por: Koskela, Ali, et al.
Publicado: (2014)

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice
por: Blasiak, Janusz, et al.
Publicado: (2021)

Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage
por: Abu Khamidakh, Amna E., et al.
Publicado: (2018)

TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells
por: Ranta-aho, Sofia, et al.
Publicado: (2021)

EGF-induced sodium influx regulates EGFR trafficking through HDAC6 and tubulin acetylation
por: Lee, Seung Joon, et al.
Publicado: (2015)

Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia
por: Łysyganicz, Paweł K., et al.
Publicado: (2021)

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin
por: Wickström, Sara A, et al.
Publicado: (2010)

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
por: Kaarniranta, Kai, et al.
Publicado: (2013)

Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance
por: He, Yan, et al.
Publicado: (2023)

Toward the defined and xeno-free differentiation of functional human pluripotent stem cell–derived retinal pigment epithelial cells
por: Vaajasaari, Hanna, et al.
Publicado: (2011)

Inflammaging: disturbed interplay between autophagy and inflammasomes
por: Salminen, Antero, et al.
Publicado: (2012)

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
por: Salminen, Antero, et al.
Publicado: (2013)

Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases
por: Salminen, Antero, et al.
Publicado: (2016)

AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging
por: Salminen, Antero, et al.
Publicado: (2019)

Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency
por: Salminen, Antero, et al.
Publicado: (2019)

ER stress activates immunosuppressive network: implications for aging and Alzheimer’s disease
por: Salminen, Antero, et al.
Publicado: (2020)

Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD)
por: Kauppinen, Anu, et al.
Publicado: (2020)

Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases
por: Salminen, Antero, et al.
Publicado: (2021)

Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin
por: Salminen, Antero, et al.
Publicado: (2022)

RASSF1A Suppresses Cell Migration through Inactivation of HDAC6 and Increase of Acetylated α-Tubulin
por: Jung, Hae-Yun, et al.
Publicado: (2013)

HDAC11 inhibition disrupts porcine oocyte meiosis via regulating α-tubulin acetylation and histone modifications
por: Huang, Rong, et al.
Publicado: (2021)

Targeting HSP90-HDAC6 Regulating Network Implicates Precision Treatment of Breast Cancer
por: Yu, Shiyi, et al.
Publicado: (2017)

Priming with HDAC Inhibitors Sensitizes Ovarian Cancer Cells to Treatment with Cisplatin and HSP90 Inhibitors
por: Rodrigues Moita, Ana J., et al.
Publicado: (2020)

Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure
por: Howes, Stuart C., et al.
Publicado: (2014)

Nutritional stress-induced regulation of microtubule organization and mRNP transport by HDAC1 controlled α-tubulin acetylation
por: Wippich, Frank, et al.
Publicado: (2023)

Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro
por: Jauhonen, Hanna-Mari, et al.
Publicado: (2011)

HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells
por: Chen, Dan-Dan, et al.
Publicado: (2021)

Genetic Variability in DNA Repair Proteins in Age-Related Macular Degeneration
por: Blasiak, Janusz, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_9c4j1947d45ttea3uj39tsrb4d