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Identifying the genetic determinants of transcription factor activity

Analysis of parallel genotyping and expression profiling data has shown that mRNA expression levels are highly heritable. Currently, only a tiny fraction of this genetic variance can be mechanistically accounted for. The influence of trans-acting polymorphisms on gene expression traits is often medi...

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Detalles Bibliográficos
Autores principales: Lee, Eunjee, Bussemaker, Harmen J
Formato: Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964119/
https://www.ncbi.nlm.nih.gov/pubmed/20865005
http://dx.doi.org/10.1038/msb.2010.64