Non-Canonical NF-κB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2

Chromosomal translocations between loci encoding MALT1 and c-IAP2 are common in MALT lymphomas. The resulting fusion proteins lack the c-IAP2 RING domain, the region responsible for its ubiquitin protein ligase (E3) activity. Ectopic expression of the fusion protein activates the canonical NF-κB sig...

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Detalles Bibliográficos
Autores principales: Conze, Dietrich B., Zhao, Yongge, Ashwell, Jonathan D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964333/
https://www.ncbi.nlm.nih.gov/pubmed/21048983
http://dx.doi.org/10.1371/journal.pbio.1000518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964333/
https://www.ncbi.nlm.nih.gov/pubmed/21048983
http://dx.doi.org/10.1371/journal.pbio.1000518

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